Spatial expression of the FGFR2b splice isoform and its prognostic significance in endometrioid endometrial carcinoma.

In multivariable Cox regression analyses adjusting for known confounding prognostic factors (myometrial invasion, FIGO grade, and stage and molecular subtype), tumors with FGFR2b +/ FGFR2c − expression remained significantly associated with longer DSS (HR 0.37; 95% CI 0.153–0.872; LRTP <0.023) and OS (HR 0.71; 95% CI 0.409–0.921; LRTP <0.045) and showed a trend toward significance for PFS compared to FGFR2b −/ FGFR2c + (Table 3 ).

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