The chemokine receptor CXCR4 regulates satellite cell activation, early expansion, and self-renewal, in response to skeletal muscle injury.

In contrast to RNA-seq on Pax7 -ZsGreen cells immediately after FACS isolation, in which very few gene expression differences could be identified, RNA-seq on activated cells showed many differences, most particularly a highly significant enrichment for changes in genes normally upregulated by activation ( Machado et al., 2017 ).

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