Risk of retinal detachment and exposure to fluoroquinolones, common antibiotics, and febrile illness using a self-controlled case series study design: Retrospective analyses of three large healthcare databases in the US.

ration of exposure/non-exposure periods 2) Did the authors ensure that there was at least a 60 day observation period after the final exposure day prior to ending the observation period? 3) The risk of violating the independence assumption between RD and antibiotic exposure (not relevant for FINTA) may be significant, especially for those patients who experienced an RD event in the pre-exposure (-60 to 0 days) period for 2 reasons: i) a RD in the pre-exposure period would intuitively reduce the risk of a similar event in the post-exposure period as a patient would likely have only half the risk (one eye) as opposed to 2 eyes which might be affected by the exposure, and ii) the odds of prescribing a FQ compared to another antibiotic in those with an RD even in the pre-exposure period might be significantly reduced due to pre-existing concerns.

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