Evaluation of Different Doses of the Aromatase Inhibitor Letrozole for the Treatment of Ectopic Pregnancy and Its Effect on Villous Trophoblastic Tissue.

The morphometrical and statistical investigation of the final score of VEGF expression in the letrozole-treated group GIV showed an exceedingly significant decrease in the expression (64. 31 ± 4. 37) compared to the control group GI (121.27 ± 9.1) ( P < 0.001) (Table 2 ).

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Quantitative Real-Time PCR Results: In this study, the RT-qPCR results showed a markedly significant decrease in the levels of ERα, Erβ, and PR mRNA expression levels of the letrozole-treated group GIV (0.2 ± 0.1, 0.3 ± 0.1, and 0.4 ± 0.2), respectively, compared to the control group (0.5 ± 0.1, 0.6 ± 0.1, and 0.9 ± 0.2) ( P < 0.001).

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