Barely Significant
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Trends in opioid utilization in Hungary, 2006-2020: A nationwide retrospective study with multiple metrics.

Eur J Pain · 2022 · PMC9541344 · PMID 35848717

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an encouraging trendno p-value reported
Increased opioid use certainly means that doctors are more vigilant about pain as a symptom, which is an encouraging trend.

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a decreasing trendno p-value reported
In rectal formulations, only a few active ingredients (codeine and tramadol) were available, and the utilization of this form was minor and showed a decreasing trend (Tables 1 and 3 ). 3.4.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.