IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples.

Pearson's correlation analysis revealed a strong, highly significant correlation between VDG percentages and IgG ACPA levels among healthy individuals (r = 0.672 and r = 0.728 in cohorts 1 and 2, respectively) and among individuals with arthralgia (r = 0.640) (Figure 2A and Supplementary Figure 3 , https://onlinelibrary.wiley.com/doi/10.1002/art.42098 ).

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