Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against <i>Plasmodium</i>.

We also show that the dramatic decrease in oocyst numbers in dsCactus females (median=0, p< 0.0001, ANOVA, Dunn’s multiple comparison test) relative to LacZ controls (median=127) (Figure 6C), is also associated with a strong and highly significant increase (13-fold) in TM7318 mRNA associated with the midgut of dsCactus infected females, relative to dsLacZ (p=0.0001, Mann-Whitney test) 24 h post-infection (Figure 6D), indicative Megacyte recruitment to the midgut.

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