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In Situ Grignard Metalation Method for the Synthesis of Hauser Bases.

Chemistry · 2022 · PMC9546396 · PMID 35686618

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an unexpected trendno p-value reported
Cyclic amines (piperidines, entries 6–8) show an unexpected trend because increasing methylation in 2,6‐positions (and hence increasing steric hindrance) enhances the yields under the applied reaction conditions.

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