Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta.

Proc Natl Acad Sci U S A · 2022 · PMC9546589 · PMID 36161909

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closest p · 0.0× alpha

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highly significantP = 8.2 × 10 −285actually significant

As expected, these DEGs clustered samples by karyotype, but also featured highly significant overlap and concordance in direction ( Fig. 4 A ), including 936 concordant DEGs out of 1,283 common to all three comparisons (73% concordant, sign test P = 8.2 × 10 −285 ).

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