Circular RNA circRASSF5 Functions as an Anti-Oncogenic Factor in Hepatocellular Carcinoma by Acting as a Competitive Endogenous RNA Through Sponging miR-331-3p.

Introduction Hepatocellular carcinoma (HCC) is pathologically characterized by high degree of malignance and clinically characterized by later state when diagnosis, high degree of cirrhosis and high recurrence rate, which ranks the fifth cancer-caused death and presents an increasing trend world widely. 1–3 Despite great improvements have been achieved in the remedy strategies (surgery resection, liver transplantation, interventional therapy, chemotherapy, immunotherapy, etc) for HCC, the prognosis is still poor owing to the heterogeneity of HCC. 4–7 Collectively, as is now well know

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