Signaling pathways and therapeutic interventions in gastric cancer.

However, its utility as a prognostic marker may be population-dependent, since overexpression of galectin-3 was highly significant in the North American cohort but not in the Asian cohort. 429 Targeting both LAG-3 and PD-1 has become an important cancer immunotherapy strategy. 372 , 430 However, the understanding of LAG-3’s mechanism in GC is still minimal, and many fundamental questions remain unanswered.

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