Methotrexate showed efficacy both in Crohn's disease and ulcerative colitis, predictors of surgery were identified in patients initially treated with methotrexate monotherapy.

Front Pharmacol · 2022 · PMC9548616 · PMID 36225564

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a decreasing trendno p-value reported

Among patients with CD, the effective ratio of methotrexate monotherapy increased, whereas patients with UC showed a decreasing trend, except in the period after 2016 ( Supplementary Figure S1 ).

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