Pro-atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation.

atherosclerosis extracellular signal‐regulated kinase 1/2 inflammation LDL receptor deficient mice signal transducer and activator of transcription‐1 British Heart Foundation (BHF) 10.13039/501100000274 PG/12/50/29691 PG/16/25/32097 FS/17/75/33257 Saudi Arabia Cultural Bureau in London (SACB) 10.13039/100012363 As shown in Table 1 and Table S1 , the ERK1 deficiency resulted in a borderline significant increase in the expression of one gene ( Npy , p = .050) and a significant decrease in the expression of 17 genes: Ace ( p = .044); Apoa1 ( p = .003); Cdh5 ( p = .002); Csf2 ( p < .001); Eln ( p < .001); Fgb ( p = .001); Hbegf ( p = .043); Ifng ( p = .039); Il3 ( p < .001); Il4 ( p = .007); Il5 ( p < .001); Itga2 ( p < .001); Lama1 ( p = .008); Ppara ( p < .001); Sele ( p = .009); Selplg ( p = .019); and Vegfa ( p = .004).

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