Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder-Updated Systematic Review and Meta-Analysis.

Chronic Stress (Thousand Oaks) · 2022 · PMC9551353 · PMID 36237981

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hedged sentences

0.0600

closest p · 1.2× alpha

0.1000

boldest claim

The sentences

marginally significantP = .06so close (0.05 < p ≤ 0.1)

In addition, random-effects models demonstrated significantly lower left hippocampus N-acetyl aspartate (NAA) in PTSD when referenced to creatine (Cr) (k = 7 studies; pooled standardized mean difference −0.99, 95% CI −1.94 to −0.04, P = .04) with a marginally significant decrease on the right (k = 6 studies; pooled standardized mean difference −0.75, 95% CI −1.54 to 0.04, P = .06), while NAA referenced otherwise demonstrated significant effect for both left (k = 7 studies; pooled standardized mean difference −0.78, 95% CI −1.11 to −0.45, P = .001) and right (k = 6 studies; pooled standardized mean difference −0.73, 95% CI −1.25 to −0.22, P = .01) hippocampus.

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a marginal trendP = .10so close (0.05 < p ≤ 0.1)

PTSD group average ages most frequently represented the 30 to 40 year range and demonstrated a marginal trend to increase relative to control (random-effects model standardized mean difference 0.10 ± 0.062, P = .10) ( Figure 3A ; Supplementary Tables 1 and 2 ).

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