Then, we checked the expression of CD80, CD86 and MHC-II using flow cytometry after 18h CpG stimulation and observed significant increase in SMRT KD BMcDC1 compared to controls whereas MHC-I showed an increasing trend ( Figure 1C and Supplementary Figure 2C ).
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SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling.
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