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Comparative efficacy and safety of JAK inhibitors as monotherapy and in combination with methotrexate in patients with active rheumatoid arthritis: A systematic review and meta-analysis.

Front Immunol · 2022 · PMC9556706 · PMID 36248913

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a favorable trendno p-value reported
Our analysis demonstrated that in patients with active RA, JAKi, in combination with MTX, was more prone to attain remission and low disease activity than JAKi monotherapy, although most indexes were associated with a favorable trend of response rate without a significant difference.

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