Novel POU3F4 variants identified in patients with inner ear malformations exhibit aberrant cellular distribution and lack of <i>SLC6A20</i> transcriptional upregulation.

Front Mol Neurosci · 2022 · PMC9558712 · PMID 36245926

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0.0013

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highly significantp -value = 0.001281actually significant

Among the transcripts differentially expressed in wild type POU3F4-transfected cells compared to control, a highly significant upregulation (log2-fold change = 3.488, false discovery rate-adjusted p -value = 0.001281) was detected for the amino acid transporter solute carrier family 6 (proline imino transporter), member 20 ( SLC6A20 , SIT1, XTRP3).

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