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Safety of paclitaxel-coated devices in the femoropopliteal arteries: A systematic review and meta-analysis.

PLoS One · 2022 · PMC9560511 · PMID 36227807

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a decreasing trendno p-value reported
In the cumulative meta-analysis by years of publications, we observed a decreasing trend of RR for the two- and five-year all-cause mortality, indicating that paclitaxel-coated/eluting devices implemented in recent years were less toxic to patients with PAD.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.