Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling.

Proc Natl Acad Sci U S A · 2022 · PMC9564325 · PMID 36191221

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In marked contrast, introduction of Mertk −/− or Axl −/− Mertk −/− or Gas6 −/− mutations into APP/PS1 all resulted in the death of ≥40% of the compound mutants by P150, and this exacerbation of early lethality relative to APP/PS1 was highly significant ( Fig. 1 ).

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