Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development.

This was further confirmed by GSEA, showing a highly significant positive enrichment of multiple macrophage signatures at 12 weeks ( Fig. 2E ) and by reverse transcription quantitative polymerase chain reaction (RT-qPCR) showing a progressive accumulation of the macrophage marker transcripts Cd68 , Adgre1 , and Cd11b (fig.

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