Identification of a Novel Renal Metastasis Associated CpG-Based DNA Methylation Signature (RMAMS).

Int J Mol Sci · 2022 · PMC9569431 · PMID 36232491

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highly significantno p-value reported

Analyses of NKX6-2 DNA methylation in three gene regions including a total of 16 CpG sites in 154 tumor-adjacent normal tissue, 189 RCC, and 194 metastatic tissue samples from 95 metastasized RCC patients revealed highly significant tumor-specific, primary metastatic-specific, and metastatic tissue-specific hypermethylation of NKX6-2 .

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