Preliminary Structure-Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of <i>Trypanosoma brucei brucei</i>.

Conversely, there was a highly significant difference between the effects of compounds 7 and 10 on the one hand and the positive control (saponin) on the other hand, at p < 0.05 ( Figure 9 ), denoting no impairment or a rather mild effect of the test compounds on the plasma membrane permeability of the parasite. 2.5.3.

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