Normalization and de-noising of single-cell Hi-C data with BandNorm and scVI-3D.

scVI-3D maintains a highly significant interaction detection accuracy rate for the IMR90 cells owing to its zero-inflation model and successful imputation strategy (Fig. 7 e).

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We observed a markedly significant overlap between these two sets of marker genes (detected by single-cell transcriptomics and scGAD scores from Dip-C, respectively) (Fig. 8 d and Additional file 1 : Fig.

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