Some studies have investigated the potential of estrogens administered following puberty suppression, to restore bone mineralization Although an increasing trend in aBMD or BMAD Z-scores after the first 2–3 years of estrogen therapy has been observed, the increase is not always significant and Z-scores (for the sex assigned at birth) often remain below baseline values ( 57 , 61 , 62 ).
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Impact of gender-affirming treatment on bone health in transgender and gender diverse youth.
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