Barely Significant
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Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders.

Front Immunol · 2022 · PMC9578444 · PMID 36268024

Europe PMCDOI
1
hedged sentence
0.0540
closest p · 1.1× alpha
0.0540
boldest claim

The sentences

marginally significantp-value=0.054so close (0.05 < p ≤ 0.1)
We observed a marginally significant enrichment of rare damaging missense mutations (MAF<1e-3, REVEL>0.5, Enrichment=3.6, p-value=0.054, binomial test) in the complement pathway.

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