One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density.

Interestingly, butyrylcarnitine (C4) showed an elevated trend in the GR group after probiotic supplementation ( P < 0.05 by the Wilcoxon signed-rank test; Supplementary Fig. 7 and Supplementary Table 8 ), which is consistent with our early report that butyrylcarnitine (C4) was increased in older women supplemented with L. reuteri ATCC PTA 6475 compared to placebo 16 .

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