The effect of helix-inducing constraints and downsizing upon a transcription block survival-derived functional cJun antagonist.

Cell Rep Phys Sci · 2022 · PMC9582194 · PMID 36274790

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highly significantno p-value reported

Previously, we observed a highly significant reduction in peptide activity in the TBS assay from peptides with IC 50 values similar to that observed for peptide HW6 (129.8 μM), meaning that HW6 is unlikely to be unable to fully outcompete cJun/TRE DNA binding.

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