Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by vitamin D.

Our study suggests that, in a controlled, in vitro model, the active metabolite of vitamin D is capable of reversing potentially aberrant/pathological IBS gene expression with emphasis on serotonergic metabolism given the GO analysis highlighting serotonergic signaling and the markedly significant increase in SERT and TPH1 expression in HCT-116 colorectal cells when treated with 1,25D.

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