Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein.

J Biol Chem · 2022 · PMC9587012 · PMID 36116552

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may be significantno p-value reported

Indeed, preponderance of interactions between amyloid-β (Aβ), tau, α-synuclein (αS), and transactive response DNA-binding protein 43 kDa (TDP-43) suggests that heterotypic amyloid aggregates may be significant in pathology ( 13 , 14 , 15 , 16 , 17 , 18 , 19 ).

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