Nasal cytology as a reliable non-invasive procedure to phenotype patients with type 2 chronic rhinosinusitis with nasal polyps.

Potential limitations of our study include: the low number of patients with type-2 low phenotype in our series, which was certainly expected in European patients 18 but weakens the comparison between patients based on the level of type 2 inflammation ( Table 1 ), even if the comparison between eosinophilic counts of the 3 collected samples gave highly significant results; the use of 2 different staining techniques for histology and cytology; however we believe that sticking as much as possible to the usual clinical practice (in which the staining of the histological preparations takes place with H&E and the nasal cytological ones with a pre-mixed rapid May-Grünwald-Giemsa staining) increases the clinical applicability of our results, also in consideration that from the scientific literature no significant differences emerge between the two methods regarding the eosinophilic count.

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