Barely Significant
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Evaluation of pulpal anesthesia and injection pain using IANB with pre-heated, buffered and conventional 2% lignocaine in teeth with symptomatic irreversible pulpitis-a randomized clinical study.

PeerJ · 2022 · PMC9587718 · PMID 36281366

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highly significantP < 0.001actually significant
Results Preheated, Buffered, and conventional 2% lignocaine showed statistically significant reduction in intraoperative pain ( P < 0.001) compared to pre-operative but on inter-group comparison preheated and buffered showed highly significant pain reduction compared with conventional 2% lignocaine ( P < 0.001).

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