Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages.

Front Endocrinol (Lausanne) · 2022 · PMC9588968 · PMID 36299457

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an increasing trendno p-value reported

But numerically E2 decreased with age after cynomolgus monkey reached 10 years of age, while FSH and LH showed an increasing trend when cynomolgus monkey entered old age, similar to the results of a study performed in 2016 ( 40 ).

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a decreasing trendno p-value reported

Therefore, BMD in cynomolgus monkeys did not show a decreasing trend with age, which may be related to our unable to accurately draw the region of interest (ROI) when using DXA measurements, so we cannot exclude the effect of osteophytes on the BMD data.

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