Several microbial species, at the strain level, were associated (n = 30, p < 0.05) with age ( Figure 2 B; Table S4 ); dominated by Ruminococcus , Alistipes , and Eubacterium species, which showed an increasing trend with age ( Figure 2 C).
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Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes.
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