Zebrafish Model of Stickler Syndrome Suggests a Role for Col2a1a in the Neural Crest during Early Eye Development.

The highly significant loss of GFP reporter expression driven by the col2a1a promoter in the MO-injected TgBAC( col2a1a::EGFP ) strain (bottom right panel, Figure 4 A,B), compared with that in uninjected and standard control MO-injected embryos of the same strain (upper right and middle right panels, respectively, Figure 4 A,B), provided proof of concept of the feasibility of Col2a1a knockdown.

also in 132,142 other papers