The interconnected relationships between middle ear bulla size, cavitation defects, and chronic otitis media revealed in a syndromic mouse model.

Again, a highly significant difference was evident, with the het ears having a much smaller hypotympanum airspace than the wild types (N = 8 WT and 11 het ears, 1 het ear had no airspace and, therefore, no measurement was possible, both ears were analyzed to provide two data points for each mouse) ( Figure 2E , Supplementary Figure S2B ) ( p < 0.0001).

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