Risk of major adverse events associated with gabapentinoid and opioid combination therapy: A systematic review and meta-analysis.

Front Pharmacol · 2022 · PMC9593000 · PMID 36304170

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an increasing trendno p-value reported

In the RCT-only analysis, the risk of sedation, dizziness, and cognitive dysfunction showed an increasing trend for combination therapy compared with that for opioid therapy; however, the differences were not significant ( Figure 1 ).

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