A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing.

The motifs at the start/end of introns, having the highest confidence of enrichment in siTM7SF3 cells, served as binding sites for splicing regulators (SRSF1, HNRNPC, PCBP1, PCBP2, HEN1, SRSF5, SFPQ, and SF1, Table S6 ) that formed a highly significant network with the RNA binding proteins that co-immunoprecipitated with TM7SF3 ( Figure S4 ).

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