Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8⁺ antigen-specific T cells for adoptive immunotherapy.

Although less striking, we also noticed a weak trend of increased expression of genes related to exhaustion in clonotypes with decreased abundance on day 28 and a rise in the expression of genes related to proliferation in clonotypes with increased abundance on day 28, irrespective of experimental conditions ( Figure 6 D).

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