Efficacy of metformin therapy in patients with cancer: a meta-analysis of 22 randomised controlled trials.

BMC Med · 2022 · PMC9594974 · PMID 36280839

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marginally significantno p-value reported

Subgroup analyses demonstrated that metformin treatment was associated with a marginally significant improvement in PFS in reproductive system cancers (HR 0.86, 95% CI 0.74–1.00) and a significantly worse PFS in digestive system cancers (HR 1.45, 95% CI 1.03–2.04).

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