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Research Question, Objectives, and Endpoints in Clinical and Oncological Research: A Comprehensive Review.

Cureus · 2022 · PMC9595265 · PMID 36312658

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an increasing trendno p-value reported
Moreover, the rates of cancers have shown an increasing trend in the past decade.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.