Interaction of client-the scaffold on which FeS clusters are build-with J-domain protein Hsc20 and its evolving Hsp70 partners.

Although such changes are observed in both prokaryotic and eukaryotic lineages, an overall trend is apparent: networks are composed of a larger number of JDP/Hsp70 systems in complex multicellular eukaryotes, i.e., more in animals and plants than in bacteria, archaea or unicellular eukaryotes ( Powers and Balch, 2013 ; Rebeaud et al., 2021 ).

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