<i>Methylocystis</i> sp. Strain SC2 Acclimatizes to Increasing NH₄⁺ Levels by a Precise Rebalancing of Enzymes and Osmolyte Composition.

Unlike with glutamate and glutamine, the intracellular concentration of proline significantly decreased from 1 mM to 50 mM NH 4 + but showed a sharp and highly significant increase to 84.12 μmol/g CDW at 75 mM NH 4 + ( P value ≤ 0.001) ( Fig. 5 ; see also Data Set S5 at https://doi.org/10.6084/m9.figshare.20750203.v2 ).

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