Rare Heterozygous <i>PCSK1</i> Variants in Human Obesity: The Contribution of the p.Y181H Variant and a Literature Review.

Genes (Basel) · 2022 · PMC9601648 · PMID 36292633

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hedged sentence

0.0720

closest p · 1.4× alpha

0.0720

boldest claim

The sentences

borderline significancep = 0.072so close (0.05 < p ≤ 0.1)

Interestingly, borderline significance (OR 7.3, p = 0.072) was obtained for the p.Y181H (rs145592525, GRCh38.p13 NM_000439.5 :c.541T>C) variant, found in nine obese and two lean persons, which predominantly drove the overall association.

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