Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation.

Protein Sci · 2022 · PMC9601872 · PMID 36173167

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may be significantno p-value reported

This opening and change in pyrin orientation on ATP binding may be significant in terms of activation, with the requirement of pyrin–pyrin interactions in ASC polymerization.

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