highly significantp < 2.2 × 10 −16
One notes highly significant terms for time (β-est. = 0.21, (95%C.I. 0.17, 0.25), p < 2.2 × 10 −16 ), monthly cannabis use (β-est. = 2.97, (1.91, 4.03), p = 8.2 × 10 −8 ), cannabis use quintiles (β-est. = 3.86, (2.45, 5.27), p = 1.2 × 10 −7 ), dichotomized cannabis use quintiles (β-est. = 3.54, (2.19, 4.89), p = 4.4 × 10 −7 ) and time: quintile interactions. 3.4.