Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate <i>In Vitro</i> Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in Response to Hyperoxia.

This capability is likely provided by a currently undefined “K13-associated genetic background,” as indicated by the highly significant (Mann-Whitney U P = 0.0001) difference in reduction of parasitemia between the two groups of strains ( Fig. 1E ) after the second cycle of proliferation.

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