highly significantp = 0.0001
Changes in overall cell growth did not reach significance after ADAM10 single knockdown ( Figure 4 a,b) being, however, highly significant after ADAM17 knockdown ( p = 0.0001; Figure 4 c,d) and to a lesser extend also following ADAM10/17 double knockdown ( p = 0.0012 and p = 0.0027; Figure 4 e,f).