Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer's Disease APP/PS1 Mouse Model.

A highly significant increase was observed in the number of synapses of neurons treated with a low or high concentration of ACR16, a 90% [189.5% ± 16.7 (160.6–253.1); 24 dendrites from n = 5 distinct cultures] or 67% [166.9% ± 7.1 (148.7–185.5); 23 dendrites from n = 5 distinct cultures] increase when compared to control conditions [100.0% ± 5.1 (87.9–114.3); 26 dendrites from n = 5 distinct cultures].

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