Barely Significant
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Risk Factors Regarding Dog Euthanasia and Causes of Death at a Veterinary Teaching Hospital in Italy: Preliminary Results.

Vet Sci · 2022 · PMC9608742 · PMID 36288167

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Generally, the absence of gonadal hormones and altered feedback on the pituitary or adrenal hormonal axes could be considered significant factors [ 48 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.