highly significantp ≤ 0.001
Serum from mice immunized with both conjugates induced highly significant responses to cCPS ( p ≤ 0.001, one-way ANOVA) two weeks after the second vaccine dose, while the group of mice vaccinated with pCPS only, CRM197 and OVA proteins only, and the control group did not have an antibody immune response ( Figure 3 ). 3.3.